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KMID : 0921620120420040359
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Journal of Bacteriology and Virology
2012 Volume.42 No. 4 p.359 ~ p.362
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Regulation of Obesity and Non-alcoholic Fatty Liver Diseases by Modulation of the Gut Microbiota Through Inflammasome; its Mechanism and Potential for Clinical Use
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Nam Jae-Hwan
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Abstract
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The revelation that gut microbes are associated with the pathogenesis of human diseases such as obesity, colon cancer, inflammatory bowel disease and liver-related diseases has resulted in the role of gut microbes becoming a novel research topic in basic and clinical science. Recently, emphasis has been placed on the role of gut microbes in non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH). Researchers have suggested that inflammasome deficiency-changed dysbiosis is associated with exacerbating NAFLD/NASH progression. This particular study also showed a direct 'gut-liver axis' regulated by modulation of gut microbiota. This paper (Nature 2012;482: 179-185) was summarized herein and the potential clinical applications were discussed.
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KEYWORD
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Inflammasome, Gut microbiota, Dysbiosis, NAFLD, NASH
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